Antibacterial peptides, also known as antimicrobial peptides or host defense peptides, are a class of small-molecule polypeptides with broad-spectrum antibacterial activity and immunomodulatory activity induced by organisms. They are an integral part of the body's non-specific defense system and exist almost everywhere. In the form of life. Antibacterial peptides usually consist of 12-50 amino acids, and the relative molecular mass is generally around 4 kDa. The study found that antimicrobial peptides have rapid bactericidal and broad-spectrum antibacterial activity, including resistance to Gram-positive bacteria, Gram-negative bacteria, multi-drug resistant bacteria, fungi, parasites, enveloped viruses and tumor cells, and can be congenital The immune and acquired immune response acts as a bridge between the body and the ability to fight microbial infections by initiating an adaptive immune system. To date, more than 4,000 antimicrobial peptides have been discovered.
Cecropin is the first antibacterial peptide discovered in the world. It was induced and isolated by the Swedish scientist Boman et al. in 1980. It consists of 37 amino acids with a molecular weight of 3800 Da. The bactericidal mechanism of cecropin is unique, does not produce drug resistance, is green and safe, has no drug residue, has significant effects on common pathogenic microorganisms, and can significantly improve immunity by chemotaxis of dendritic cells, monocytes and memory T cells. Force is the world's recognized best alternative to antibiotics.
At present, there are three main methods for producing antimicrobial peptides: natural extraction, chemical synthesis, and bioengineering synthesis.
The natural antibacterial peptide is mainly from insects, but the extraction process is very complicated; the chemical synthesis method is costly and unsuitable for industrialization; the bioengineering synthesis method is to improve the expression of the existing antibacterial peptide by using microorganisms to express and increase the expression level. The use of fermentation technology to achieve industrialization, with the advantages of stable quality and low cost, is the best way for the industry to recognize large-scale production.
In the state-level Hongqi Canal Economic and Technological Development Zone, there are 1037 acres of bio-industry zones, and a world-class production line of antibacterial peptides, probiotics, biological feed and protein raw materials has been built.
It has advanced bio-fermentation, purification, drying and testing equipment for antibacterial peptides at home and abroad, and has established an antibacterial peptide bio-industrial park integrating food additives, bio-pharmaceuticals, science and technology buildings, animal experiment centers, activity centers and business schools.